Replacement “Cialis”-soft, or otherwise generic, are in a class of inhibitors of nitric oxide and their pharmacological effect is identical to the effects on the body of the original drug. Generic “Cialis” soft-considered to be as effective as the original tablets and at the same time to acquire them is more appropriate from an economic point of view. For the current reagent in both types of tablets is the same chemical – tadalifil.
The exposure on the body is due to the increasing intensity of blood flow in the corpus cavernosum penis, thus fulfilling a long and sustained erection.
Description of Cialis:
Commercial (proprietary) name of the drug: Cialis
International (nonproprietary) name: Tadalafil
Pharmacological Effects: Cialis is an effective, reversible, selective inhibitor of specific phosphodiesterase type 5 (PDE5), cyclic guanosine monophosphate (cGMP). When sexual excitement is in a man release of nitric oxide, inhibition of PDE5 tadalafil leads to higher levels of cGMP in the cavernous body of penis. The result is relaxation of smooth muscles of arteries and blood flow to the tissues of the penis that causes erections. It should be noted that the use of Cialis does not lead to involuntary erection – Cialis no effect in the absence of sexual stimulation.
Indications: Cialis is designed to enhance potency in men suffering from erection disorders (erectile dysfunction), including the extreme form of erectile dysfunction – impotence. These disturbances lacked sufficient for sexual intercourse erection or weak erection. Erectile dysfunction may be caused by various conditions, both psychological and physiological nature. According to the results of clinical trials, Cialis, possessing a similar mechanism of action with the first and most famous treatment for erectile dysfunction Viagra, according to its curative properties are not inferior to its predecessor, and about the duration of effect far beyond it. Cialis provides blood flow to the penis and as a consequence of the offensive full erection, and the erection does not arise spontaneously, but only in response to sexual arousal, ie Cialis does not substitute natural processes of sexual arousal, but only intensifies them. Cialis has no effect on male reproductive function.
Contraindications: – Hypersensitivity Due to tadalafil or to any substances in the composition of the drug; In the case of taking the drugs containing any organic nitrates; use in persons under 18 years
Recommendations for use: The recommended dose for Cialis is 20 mg. Cialis taken before anticipated sexual activity, regardless of prima food. Drug should take at least 16 minutes prior to the alleged sexual activity. Patients may attempt to carry out a sexual act at any time within 36 hours after taking the drug in order to establish the optimal response time to receive the drug. The maximum recommended frequency of admission – once a day.
Side effects: The most frequently reported adverse events were headache and dislepsiya (11 and 7% respectively). Adverse events associated with taking tadalafil were generally small or medium degree, transit and decreased with continued use of the drug. Other common adverse effects include back pain, myalgia, nasal congestion and «tide» blood to the face. Seldom – swelling of the eyelids, eye pain, hyperemia konjuktivy and dizziness.
Cautions:Sexual activity has potentstsialny risk for patients with cardiovascular diseases. Therefore, treatment of erectile dysfunction, including the use of Cialis, should not be undertaken in men with heart disease, in which sexual activity is not recommended.
Interaction: Cialis (tadalafil) is mainly metabolized with the participation of the enzyme CYP3A4. Selective inhibitor of CYP3A4, ketoconazole, increases the area under the curve «concentration-time» by 107%, and rifampicin, it reduces by 88%. Despite the fact that the specific interactions have not been studied, one can assume that these inhibitors like ritonavir and saquinavir, as well as inhibitors of CYP3A4 such as erythromycin and intrakonazol increases the activity of Cialis (tadalafil). Simultaneous treatment with an antacid (magnesium hydroxide / aluminum hydroxide) and tadalafil reduce the rate of absorption of tadalafil without altering the area under the curve «concentration-time» for tadalafil. Increasing the pH of the stomach as a result of receiving H2-antagonist nizatidina, had no influence on the pharmacokinetics of tadalafil.
The difference between Cialis and Levitra to Viagra: Cialis, Viagra and Levitra have a similar mechanism to strengthen natural reaction on men’s sexual arousal, increasing blood flow to the penis and providing a full erection. The main difference of Cialis from Viagra is primarily in fewer minimum required active ingredient. If Viagra is a minimum of 25 mg (in most cases minimal neobodimaya dose 50 mg), for Cialis is 20 mg. This difference provides a lower probability of occurrence of side effects and their меншую intensity. Another important difference between Cialis is its prolonged, compared with Viagra and Levitra, time steps. If the duration of Viagra is 4 hours, while Levitra 12 hours, then the effect of Cialis lasts 36 hours, for which he has dubbed “weekend pill”. In addition, it is assumed that the speed of onset of effect from taking Cialis faster than from taking Viagra, however, these figures are quite relative and vary depending on individual characteristics of the organism.
Sildenafil citrate 100 mg
This is The exclusive drug.
Female Viagra – a new drug for the solution of such problems as women’s sexual desire disorder and female sexual dysfunction, created by scientists to meet the sexual needs and prolong pleasure.
Advantages:
-Increases in blood testestorona
-Increases the libido in most women
-Enhanced sensitivity to stimulation
-Effective for women with a hysterectomy and menopause before age 50.
Commercial (proprietary) name of the drug: Viagra
International (nonproprietary) name: Sildenafil (as sildenafil citrate).
Pharmacotherapeutic group: Viagra is the first of a new group of drugs to increase potency, known as inhibitors of phosphodiesterase 5-th type. Viagra dilates blood vessels of the penis during sexual arousal, providing blood flow to the penis, which helps advance a full erection.
Active ingredient: The active ingredient of Viagra is sildenafil. Each tablet presented in our pharmacy generic viagra contains 100 mg of sildenafil (in the form of sildenafil citrate)
Inactive components: The composition of Viagra also contains the following inactive components: microcrystalline cellulose, calcium gidrogenfosfat (anhydrous), croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide (U171), lactose, triatsetin, indigo carmine aluminum lacquer (E132).
Indications: Viagra is designed to enhance potency in men suffering from erection disorders (erectile dysfunction), including the extreme form of erectile dysfunction – impotence. These disturbances lacked sufficient for sexual intercourse erection or weak erection. Erectile dysfunction may be caused by various conditions, both psychological and physiological nature. According to the results of clinical trials, the use of Viagra effective in about 80 percent of cases of erectile dysfunction. Viagra provides blood flow to the penis and prevent its outflow, and the erection does not arise spontaneously, but only in response to sexual arousal, ie Viagra does not substitute natural processes of sexual arousal, but only intensifies them.
Also, Viagra helps the development of the brain oxytocin – a hormone which awakens the romantic senses. Viagra has no effect on male reproductive function.